CD62P Antibody [AK-4] (PE)

• Background:

  The AK-4 monoclonal antibody specifically reacts with human CD62P (P-Selectin), a 140 kDA type I transmembrane glycoprotein also known as platelet activation-dependent granule membrane protein (PADGEM) . Upon activation it is quickly transported to the plasma membrane from the alpha-granules of platelets and WEibel-Palade bodies of endothelial cells. It is essential to the functions of cell adhesion during inflammatory reactions and in the interaction of platelets with monocytes and neutrophils.

• NCBI Gene ID:

  6403

• Swiss Prot:

  P16109

• Host:

  Mouse

• Reactivity:

  Human

• Clonality:

  Monoclonal

• Clone:

  AK-4

• Conjugation:

  PE

• Type:

  Primary Antibodies

• Field of Research:

  Immunology

• Purification:

  The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

• Concentration:

  Batch dependent

• Buffer:

  Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

• Fragment:

  Mouse IgG1, kappa

• Specificity:

  The AK-4 monoclonal antibody specifically reacts with human CD62P (P-Selectin), a 140 kDA type I transmembrane glycoprotein also known as platelet activation-dependent granule membrane protein (PADGEM) .

• Symbol:

  SELP

• NCBI Official Name:

  Selectin P (granule membrane protein 140kDa, antigen CD62)

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Leucocyte Typing VI: White Cell Differentiation Antigens: Proceedings of the Sixth International Workshop and Conference Held in Kobe, Japan, 10-14 November 1996. Garland Pub., 1998.

• Background Reference 02:

  Schlossman, S. F. (1995) .Leucocyte typing V: White cell differentiation antigens: Proceedings of the Fifth International Workshop and Conference, Held in Boston, USA 3-7 November, 1993. Oxford University Press.

• Background Reference 03:

  Johnson-Tidey, R. R., McGregor, J. L., Taylor, P. R., Poston, R. N. (1994) . Increase in the adhesion molecule P-selectin in endothelium overlying atherosclerotic plaques. Coexpression with intercellular adhesion molecule-1.The American journal of pathology,144 (5), 952.

• Other Product Names:

  CD62, GRMP, PSEL, CD62P, GMP140, LECAM3, PADGEM, SELP

• Tested Applications:

  Flow

• Physical Properties:

  Liquid