H-2Kd/H-2Dd Antibody [34-1-2S] (PE)

• Background:

  The “classical” MHC Class I molecules are histocompatibility antigens encoded by the H-2 gene complex and consist of heterodimers of highly polymorphic alpha chains noncovalently associated with the invariant beta2-microglobulin. These antigens are expressed on most nucleated cells but expression varies on different cell types. MHC Class I molecules present endogenously synthesized peptides to CD8+ T lymphocytes, which are usually cytotoxic T cells. MHC Class I antigens expressed on thymic epithelial cells regulate the positive and negative selection of CD8+ T cells during T cell ontogeny. The monoclonal antibody 34-1-2S binds to a common determinant in the alpha3 domains of H-2Kd and H-2Dd in the presence or absence of beta2 microglobulin. It cross reacts with the alpha3 domain of H-2Kb.

• NCBI Gene ID:

  14964;14972

• Host:

  Mouse

• Reactivity:

  Mouse

• Immunogen:

  BDF1 mouse splenocytes

• Clonality:

  Monoclonal

• Clone:

  [34-1-2S]

• Conjugation:

  PE

• Type:

  Primary Antibodies

• Field of Research:

  Immunology

• Concentration:

  0.1 mg/mL

• Buffer:

  Supplied in PBS/NaN3 and a stabilizing agent

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store vial at 2-8˚ C

• Fragment:

  IgG2a

• Specificity:

  H-2Kd/H-2Dd

• Applications Notes:

  H-2Kd/H-2Dd Antibody [34-1-2S] for use in flow cytometry assays.

• Symbol:

  H2-D1; H2-K1

• NCBI Official Name:

  Histocompatibility 2, D region locus 1; histocompatibility 2, K1, K region

• NCBI Organism:

  Mus musculus

• Other Product Names:

  MHC Class I

• Tested Applications:

  IHC-Fr, Flow, IP

• Physical Properties:

  Liquid