Girdin (phospho Ser1417) Antibody

• Background:

  Girdin IS a ubiquitously expressed actin binding protein that plays an important role in the formation of stress fibers and lamellipodia. Subsequent to phosphorylation by Akt, Girdin accumulates at the leading edge of migrating cells and appears to be crucial for the integrity of the actin cytoskeleton and for cell migration.

• NCBI Gene ID:

  55704

• Swiss Prot:

  Q3V6T2

• Accession Number:

  NP_060554.3

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  Girdin (phospho Ser1417) antibody was raised against a peptide sequence around phosphorylation site of Serine 417 (L-E-M (p) -A-Q) derived from Human Girdin .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Phospho-Specific

• Purification:

  Antibodies were purified by affinity-chromatography using epitope-specific peptide.

• Concentration:

  1 mg/mL

• Buffer:

  Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Modification:

  Phospho-Specific

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store antibody at -20˚ C for up to one year.

• Calculated Molecular Weight:

  216 kDa

• Fragment:

  IgG

• Specificity:

  The antibody detects endogenous levels of Girdin only when phosphorylated at serine 1417.

• Symbol:

  CCDC88A

• NCBI Official Name:

  Coiled-coil domain containing 88A

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Enomoto A., Dev. Cell 9:389-402 (2005) .

• Background Reference 02:

  Simpson F., Traffic 6:442-458 (2005) .

• Background Reference 03:

  Hillier L.W., Nature 434:724-731 (2005) .

• Other Product Names:

  APE, GIV, GRDN, HkRP1, KIAA1212

• Tested Applications:

  IHC

• Protein ID:

  50897852

• Physical Properties:

  Liquid