MAP3K1 (phospho Thr1402) Antibody

• Background:

  Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway.

• NCBI Gene ID:

  4214

• Swiss Prot:

  Q13233

• Accession Number:

  NP_005912.1

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  MAP3K1 (phospho Thr1402) antibody was raised against a peptide sequence around phosphorylation site of threonine 1402 (T-G-A (p) -G-F) derived from Human MAP3K1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Phospho-Specific

• Purification:

  Antibodies were purified by affinity-chromatography using epitope-specific peptide.

• Concentration:

  1 mg/mL

• Buffer:

  Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Modification:

  Phospho-Specific

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store antibody at -20˚ C for up to one year.

• Calculated Molecular Weight:

  130 kDa

• Fragment:

  IgG

• Specificity:

  The antibody detects endogenous levels of MAP3K1 only when phosphorylated at threonine 1402.

• Applications Notes:

  Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

• Symbol:

  MAP3K1

• NCBI Official Name:

  Mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Schmutz J., Nature 431:268-274 (2004) .

• Background Reference 02:

  Xia Y., Genes Dev. 12:3369-3381 (1998) .

• Background Reference 03:

  Vinik B.S., Mamm. Genome 6:782-783 (1995)

• Other Product Names:

  M3K1, MAP3K1, MAPKKK1, MEKK1

• Tested Applications:

  WB, IHC

• Protein ID:

  153945765

• Physical Properties:

  Liquid