CCR5 Antibody

• Background:

  CCR5 Antibody: Human immunodeficiency virus (HIV) and related virus require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors. Among them, CCR5 (CC-CKR-5) is a principal coreceptor for macrophage- and dual-tropic HIV-1 strains fusion and entry of human white blood cells. CCR5 is required for the infection by HIV-1, HIV-2, and SIV. The beta-chemokines RANTES, MIP-alpha and MIP-beta are the ligands for CCR5 and prevent infection by M-tropic HIV-1. CXC5 associates with the surface CD4-gp120 of HIV complex and leads to membrane fusion and virus entry of target cells. The amino-terminal domain and the extracellular loops of CCR5 serve as HIV biding sites. CCR5 messenger RNA is expressed in lymphoid organs and monocytes.

• NCBI Gene ID:

  1234

• Swiss Prot:

  P51681

• Accession Number:

  AAB57793

• Host:

  Rabbit

• Reactivity:

  Human

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Chemokines & Cytokines, Cancer, Infectious Disease

• Purification:

  CCR5 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1208 - THP-1 Cell Lysate

• Concentration:

  1 mg/ml

• Buffer:

  CCR5 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  CCR5 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Symbol:

  CCR5

• Positive Control 2:

  Cat. No. 1369 - Human Lymph node Tissue Lysate

• Positive Control 3:

  Cat. No. 11-521 - Human Lymphoid Tissue Tissue Slide

• NCBI Official Name:

  Chemokine (C-C motif) receptor 5

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Dimitrov, DS. Cell 1997; 91:721-30

• Background Reference 02:

  Littman, DR. Cell 1998; 93:677-80

• Background Reference 03:

  Deng, H, et al. Nature 1996; 381:661-6

• Background Reference 04:

  Dragic, T, et al. Nature 1996; 381:667-73

• Other Product Names:

  CCR5 Antibody: CKR5, CCR-5, CD195, CKR-5, CCCKR5, CMKBR5, IDDM22, CC-CKR-5, C-C chemokine receptor type 5, CHEMR13, C-C CKR-5

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  2104520

• Physical Properties:

  Liquid