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CCR5 Antibody

CAT: 0223-1112-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-1112-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CCR5 Antibody: Human immunodeficiency virus (HIV) and related virus require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors. Among them, CCR5 (CC-CKR-5) is a principal coreceptor for macrophage- and dual-tropic HIV-1 strains fusion and entry of human white blood cells. CCR5 is required for the infection by HIV-1, HIV-2, and SIV. The beta-chemokines RANTES, MIP-alpha and MIP-beta are the ligands for CCR5 and prevent infection by M-tropic HIV-1. CXC5 associates with the surface CD4-gp120 of HIV complex and leads to membrane fusion and virus entry of target cells. The amino-terminal domain and the extracellular loops of CCR5 serve as HIV biding sites. CCR5 messenger RNA is expressed in lymphoid organs and monocytes.
NCBI Gene ID
1234
Swiss Prot
P51681
Accession Number
AAB57793
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Chemokines & Cytokines, Cancer, Infectious Disease
Purification
CCR5 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1208 - THP-1 Cell Lysate
Concentration
1 mg/ml
Buffer
CCR5 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
CCR5 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
CCR5
Positive Control 2
Cat. No. 1369 - Human Lymph node Tissue Lysate
Positive Control 3
Cat. No. 11-521 - Human Lymphoid Tissue Tissue Slide
NCBI Official Name
Chemokine (C-C motif) receptor 5
NCBI Organism
Homo sapiens
Background Reference 01
Dimitrov, DS. Cell 1997; 91:721-30
Background Reference 02
Littman, DR. Cell 1998; 93:677-80
Background Reference 03
Deng, H, et al. Nature 1996; 381:661-6
Background Reference 04
Dragic, T, et al. Nature 1996; 381:667-73
Other Product Names
CCR5 Antibody: CKR5, CCR-5, CD195, CKR-5, CCCKR5, CMKBR5, IDDM22, CC-CKR-5, C-C chemokine receptor type 5, CHEMR13, C-C CKR-5
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
2104520
Physical Properties
Liquid

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