Adiponectin Antibody

• Background :

  Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-κ -B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.

• NCBI Gene ID :

  9370

• Swiss Prot :

  Q15848

• Accession Number :

  NP_001171271.1

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Adiponectin antibody was raised against a peptide sequence around aa.235~239 (T-G-F-L-L) derived from Human Adiponectin.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Stem Cell

• Purification :

  Antibodies were purified by affinity-chromatography using epitope-specific peptide.

• Concentration :

  1 mg/mL

• Buffer :

  Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store antibody at -20˚ C for up to one year.

• Calculated Molecular Weight :

  27 kDa

• Specificity :

  This antibody detects endogenous level of total Adiponectin protein.

• Applications Notes :

  Western Blot: 1:500~1:1000

• Symbol :

  ADIPOQ

• NCBI Official Name :

  Adiponectin, C1Q and collagen domain containing

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Yamauchi T., Kamon J., Waki H., Terauchi Y., Kubota N., Hara K., Mori Y., Ide T., Murakami K., Yoda M. Kadowaki T. Nat. Med. 7:941-946 (2001) Richards A. A., Stephens T., Charlton H. K., Jones A., Macdonald G. A., Prins J. B., Whitehead J. P. Mol. Endocrinol. 20:1673-1687 (2006)

• Other Product Names :

  ACDC, ADPN, APM1, APM-1, GBP28, ACRP30, ADIPQTL1, ACDC

• Tested Applications :

  WB

• Protein ID :

  295317372

• Physical Properties :

  Liquid