E2F 1 Antibody

CAT: 0223-79-747Size: 0.1 mgDry Ice: NoHazardous: No
CAT#:0223-79-747Size:0.1 mg
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Background
Transcription activator that binds DNA cooperatively with dp proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-1 binds preferentially RB1 protein, in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent apoptosis.
NCBI Gene ID
1869
Swiss Prot
Q01094
Accession Number
NP_005216.1
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
E2F-1 antibody was raised against a peptide sequence around aa.430~434 (G-D-L-T-P) derived from Human E2F-1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Apoptosis
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
70 kDa
Specificity
This antibody detects endogenous levels of total E2F-1 protein.
Applications Notes
Western Blot: 1:500~1:1000
Symbol
E2F1
NCBI Official Name
E2F transcription factor 1
NCBI Organism
Homo sapiens
Other Product Names
RBP3, E2F-1, RBAP1, RBBP3, RAF, RBP3
Tested Applications
WB
Protein ID
12669911
Physical Properties
Liquid

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