E2F6 Antibody

CAT: 0223-27-521Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-27-521Size:100 µL
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Background
E2F6 encodes a member of the E2F transcription factor protein family. E2F family members play a crucial role in control of the cell cycle and of the action of tumor suppressor proteins. They are also a target of the transforming proteins of small DNA tumor viruses. Many E2F proteins contain several evolutionarily conserved domains: a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. The encoded protein of this gene is atypical because it lacks the transactivation and tumor suppressor protein association domains. It contains a modular suppression domain and is an inhibitor of E2F-dependent transcription. The protein is part of a multimeric protein complex that contains a histone methyltransferase and the transcription factors Mga and Max.
NCBI Gene ID
1876
Swiss Prot
Q6Q9Z5
Accession Number
NP_997705
Host
Rabbit
Reactivity
Human, Mouse, Rat, Dog
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human E2F6.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Transcription, Cell Cycle, Cancer
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. 1309 - Human Placenta Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store E2F6 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
14 kDa
Applications Notes
E2F6 antibody can be used for detection of E2F6 by ELISA at 1:62500. E2F6 antibody can be used for detection of E2F6 by western blot at 0.5 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
E2F6
NCBI Official Name
E2F transcription factor 6
NCBI Organism
Homo sapiens
Background Reference 01
Kherrouche, Z., et al., (2004) Biochem. Biophys. Res. Commun. 317 (3), 749-760.
Other Product Names
E2F6, E2F-6
Tested Applications
ELISA, WB, IHC
Protein ID
47078264
Physical Properties
Liquid

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