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Nanog Antibody

CAT: 0223-79-644Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-79-644Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes By similarity. Acts as a transcriptional activator or repressor By similarity. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3' By similarity. When overexpressed, promotes cells to enter into S phase and proliferation
NCBI Gene ID
79923
Swiss Prot
Q9H9S0
Accession Number
NP_079141.2
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Nanog antibody was raised against a peptide sequence around aa.137~141 (K-Q-V-K-T) derived from Nano g.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
42 kDa
Specificity
This antibody detects endogenous level of total Nanog protein.
Applications Notes
Western Blot: 1:1000
Symbol
NANOG
NCBI Official Name
Nanog homeobox
NCBI Organism
This antibody was raised against a peptide sequence around aa.137~141 (K-Q-V-K-T) derived from Nano g
Background Reference 01
Do HJ, et al. Biochem Biophys Res Commun. 2007 Feb 16;353 (3) : 770-5. Boyer LA, et al. Cell. 2005 Sep 23;122 (6) : 947-56. Freberg CT, et al. Mol Biol Cell. 2007 May;18 (5) : 1543-53. Chambers I, et al. Cell. 2003 May 30;113 (5) : 643-55.
Other Product Names
FLK1, VEGFR2, Homeobox transcription factor Nanog
Tested Applications
WB
Protein ID
153945816
Physical Properties
Liquid

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