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Caspase 9 Antibody

CAT: 0223-79-643Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-79-643Size:0.1 mg
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Background
Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Proteolytically cleaves poly (ADP-ribose) polymerase (PARP) . Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.
NCBI Gene ID
842
Swiss Prot
P55211
Accession Number
NP_001220.2
Host
Rabbit
Reactivity
Human
Immunogen
Caspase 9 antibody was raised against a peptide sequence around aa.301~305 (T-S-P-E-D) derived from Caspase 9.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cancer
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
47, 37, 35 kDa
Specificity
This antibody detects endogenous level of total Caspase 9 protein.
Applications Notes
Western Blot: 1:1000
Symbol
CASP9
NCBI Official Name
Caspase 9, apoptosis-related cysteine peptidase
NCBI Organism
This antibody was raised against a peptide sequence around aa.301~305 (T-S-P-E-D) derived from Caspase 9
Background Reference 01
Zou, H. et al. (1999) J. Biol. Chem. 274, 11549-11556. Deveraux, Q. L. et al. (1998) EMBO J. 17, 2215-2223. Li, P. et al. (1997) Cell 91, 479-489.
Other Product Names
MCH6, APAF3, APAF-3, PPP1R56, ICE-LAP6, DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1, ICE-like apoptotic protease 6
Tested Applications
WB
Protein ID
14790124
Physical Properties
Liquid

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