Caspase 9 Antibody

• Background:

  Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Proteolytically cleaves poly (ADP-ribose) polymerase (PARP) . Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.

• NCBI Gene ID:

  842

• Swiss Prot:

  P55211

• Accession Number:

  NP_001220.2

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Caspase 9 antibody was raised against a peptide sequence around aa.301~305 (T-S-P-E-D) derived from Caspase 9.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Apoptosis, Cancer

• Purification:

  Antibodies were purified by affinity-chromatography using epitope-specific peptide.

• Concentration:

  1 mg/mL

• Buffer:

  Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store antibody at -20˚ C for up to one year.

• Calculated Molecular Weight:

  47, 37, 35 kDa

• Specificity:

  This antibody detects endogenous level of total Caspase 9 protein.

• Applications Notes:

  Western Blot: 1:1000

• Symbol:

  CASP9

• NCBI Official Name:

  Caspase 9, apoptosis-related cysteine peptidase

• NCBI Organism:

  This antibody was raised against a peptide sequence around aa.301~305 (T-S-P-E-D) derived from Caspase 9

• Background Reference 01:

  Zou, H. et al. (1999) J. Biol. Chem. 274, 11549-11556. Deveraux, Q. L. et al. (1998) EMBO J. 17, 2215-2223. Li, P. et al. (1997) Cell 91, 479-489.

• Other Product Names:

  MCH6, APAF3, APAF-3, PPP1R56, ICE-LAP6, DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1, ICE-like apoptotic protease 6

• Tested Applications:

  WB

• Protein ID:

  14790124

• Physical Properties:

  Liquid