Products for Research Use Only
RegisterLogin

Caspase8 Antibody

CAT: 0223-79-642Size: 0.1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-79-642Size:0.1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.
NCBI Gene ID
58022
Swiss Prot
Q14790
Accession Number
NP_571585.2
Host
Rabbit
Reactivity
Human
Immunogen
Caspase8 antibody was raised against a peptide sequence around aa.221~225 (T-L-D-K-V) derived from Human Caspase8.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cancer , Inflammasomes
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
18, 43, 57 kDa
Specificity
This antibody detects endogenous level of total Caspase8 protein.
Applications Notes
Western Blot: 1:500~1:1000
Symbol
Casp8
NCBI Official Name
Caspase 8, apoptosis-related cysteine peptidase
NCBI Organism
Homo sapiens
Background Reference 01
Himeji D. et. al. (2002) Blood 99:4070-4078Breckenridge D. G. et. al. (2002) Proc. Natl. Acad. Sci. U. S. A. 99:4331-4336Muzio M. et. al. (1997) J. Biol. Chem. 272:2952-2956
Other Product Names
Caspase-8, zgc:92075, NCAM, CASP8, MCH5
Tested Applications
WB
Protein ID
52138561
Physical Properties
Liquid

Related Products

CatalogName
3465-01mgCaspase-7 Antibody
3455-01mgCaspase-5 Antibody
3467-01mgCaspase-7 Antibody
3451-01mgCaspase-4 Antibody
2071-01mgCaspase-9 Antibody
3475-01mgCaspase-8 Antibody
2073-01mgCaspase-9 Antibody
3453-01mgCaspase-4 Antibody
3471-01Caspase-6 Antibody
3467-01Caspase-7 Antibody

Alternative Products

CatalogName
MBS8586337-01Caspase8 Antibody
35-1675-100Polyclonal Antibody to Caspase8
MA1632-.1Anti-Caspase8 Rabbit Monoclonal Antibody
309315Caspase8
MBS8541594-01Caspase8 Rabbit pAb
80114-2Caspase8, His-tag Recombinant
GTR18869917-01Human Caspase 8 (Caspase8) ELISA Kit
507682Caspase 8 (Apoptotic Cysteine Protease, Apoptotic Protease Mch 5, Casp 8, CASP8, Caspase 8/p18, Caspase8, FADD like ICE, FLICE, ICE like Apoptotic Protease 5, MACH, MCH5) discontinued
221342-01Caspase 8 (Caspase-8, Caspase8, Caspase 8, CASP-8, Apoptotic Cysteine Protease, Apoptotic Protease Mch-5, CAP4, FADD-Homologous ICE/ced-3-like Protease, FADD-like ICE, FLICE, ICE-like Apoptotic Protease 5, MORT1-Associated ced-3 Homolog, MACH, Caspase-8 Subunit p18, Caspase-8 Subunit p10, CASP8, MCH5) discontinued
221344-01Caspase 8, phosphorylated (T341) (Caspase-8, Caspase8, Caspase 8, CASP-8, Apoptotic Cysteine Protease, Apoptotic Protease Mch-5, CAP4, FADD-Homologous ICE/ced-3-like Protease, FADD-like ICE, FLICE, ICE-like Apoptotic Protease 5, MORT1-Associated ced-3 Homolog, MACH, Caspase-8 Subunit p18, Caspase-8 Subunit p10, CASP8, MCH5) discontinued

Popular Products