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Fas Antibody

CAT: 0223-79-640Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-79-640Size:0.1 mg
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Background
Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro) .
NCBI Gene ID
355
Swiss Prot
P25445
Accession Number
NP_000034.1
Host
Rabbit
Reactivity
Human
Immunogen
Fas antibody was raised against a peptide sequence around aa.323~327 (E-N-S-N-F) derived from human Fas .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cancer
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
40 - 50 kDa
Specificity
This antibody detects endogenous level of total Fas protein.
Applications Notes
Western Blot: 1:1000
Symbol
FAS
NCBI Official Name
Fas cell surface death receptor
NCBI Organism
Homo sapiens
Background Reference 01
Hahne, M. et al. (1995) Int Immunol 7, 1381-6. Nagata, S. (1997) Cell 88, 355-65. Green, D. R. and Ferguson, T. A. (2001) Nat Rev Mol Cell Biol 2, 917-24.
Other Product Names
APT1, CD95, FAS1, APO-1, FASTM, ALPS1A, TNFRSF6, RP11-399O19.9, IKBE, FASLG receptor, Apoptosis-mediating surface antigen FAS, Apo-1 antigen
Tested Applications
WB
Protein ID
4507583
Physical Properties
Liquid

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