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Integrin beta3 (Ab 785) Antibody

CAT: 0223-79-602Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-79-602Size:0.1 mg
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Background
The Itg-Beta3 gene encodes the beta subunit of the platelet membrane adhesive protein receptor complex Itg-Beta3 protein, which belongs to the Integrin class of cell adhesion molecule receptors that share a common heterotrimeric structure with Alpha and Beta subunits. It is a common Beta subunit of the platelet complex and of two other Integrins (Fibronectin and Vitronectin Receptors), which have distinct Alpha subunits. Itg-Beta3 has been implicated in a wide variety of functions, including platelet aggregation and thrombosis and implantation, placentation, angiogenesis, bone remodeling, and tumor progression. Glanzmann Thrombasthenia can result from defects in the genes for either the Itg-Alpha2B or the Itg-Beta3 subunit
NCBI Gene ID
3690
Swiss Prot
P05106
Accession Number
NP_000203.2
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Integrin beta3 (Ab-785) antibody was raised against a peptide sequence around aa.783~787 (I-T-Y-R-G) derived from Human Integrin B3/ITGB3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
110 kDa
Specificity
This antibody detects endogenous level of total Integrin β3 protein.
Applications Notes
Western Blot: 1:500~1:1000
Symbol
ITGB3
NCBI Official Name
Integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
NCBI Organism
Homo sapiens
Background Reference 01
Sujoy Bhattacharya, et al. (2006) Biochem J. August 1; 397 (Pt 3) : 437–447Courter DL, et al. (2005) J Biol Chem Apr 01; 280 (13) : 12145-12151Chandhoke SK, et al. (2004) J Cell Sci Mar 15; 117 (Pt 8) : 1431-1441
Other Product Names
GT, CD61, GP3A, BDPLT2, GPIIIa, BDPLT16, CD61 antigen, ITB3, Platelet membrane glycoprotein IIIa
Tested Applications
WB
Protein ID
47078292
Physical Properties
Liquid

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