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Integrin beta3 (Ab 773) Antibody

CAT: 0223-79-317Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-79-317Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
NCBI Gene ID
3690
Swiss Prot
P05106
Accession Number
NP_000203.2
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Integrin beta3 (Ab-773) antibody was raised against a peptide sequence around aa. 771~775 (P-L-Y-K-E) derived from Human Integrin β3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
110 kDa
Specificity
This antibody detects endogenous level of total Integrin β3 protein.
Applications Notes
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Symbol
ITGB3
NCBI Official Name
Integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
NCBI Organism
Homo sapiens
Background Reference 01
Chandhoke SK, et al. (2004) J Cell Sci; 117 (Pt 8) : 1431-41. Datta A, et al. (2002) J Biol Chem; 277 (6) : 3943-9. Law DA, et al. (1996) J Biol Chem; 271 (18) : 10811-5.
Other Product Names
GT, CD61, GP3A, BDPLT2, GPIIIa, BDPLT16, CREB2, CREBP1, Platelet membrane glycoprotein IIIa
Tested Applications
WB, IHC
Protein ID
47078292
Physical Properties
Liquid

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