A catenin (phospho Ser641) Antibody

• Background:

  Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. May play a crucial role in cell differentiation.

• NCBI Gene ID:

  1495

• Swiss Prot:

  P35221

• Accession Number:

  NP_001894.2

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  A-catenin (Phospho-Ser641) antibody was raised against a peptide sequence around phosphorylation site of serine 641 (D-D-S (p) -D-F) derived from Human α -catenin.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Phospho-Specific

• Purification:

  Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

• Concentration:

  1 mg/mL

• Buffer:

  Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Modification:

  Phospho-Specific

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store antibody at -20˚ C for up to one year.

• Calculated Molecular Weight:

  100 kDa

• Specificity:

  This antibody detects endogenous level of α -catenin only when phosphorylated at serine 641.

• Applications Notes:

  Western Blot: 1:500~1:1000

• Symbol:

  CTNNA1

• NCBI Official Name:

  Catenin (cadherin-associated protein), alpha 1, 102kDa

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Hwang, S. G. et al. (2005) J. Biol. Chem. 280, 12758-12765Drees, F. et al. (2005) Cell 123, 903-915. Yamada, S. et al. (2005) Cell 123, 889-901. Kobielak, A. and Fuchs, E. (2004) Nat. Rev. Mol. Cell Biol. 5, 614-625.

• Other Product Names:

  CAP102, JNKK1, MEK4, MKK4, PRKMK4, SEK1, SERK1, SKK1, Cadherin-associated protein, Alpha E-catenin, NY-REN-13 antigen

• Tested Applications:

  WB

• Protein ID:

  55770844

• Physical Properties:

  Liquid