CD107a Antibody [H4A3] (FITC)

• Background:

  The H4A3 monoclonal antibody specifically reacts with human CD107a, a heavily glycosylated type I membrane glycoprotein. CD107a is also known as Lysosomal-associated membrane protein 1 (LAMP-1) and is widely expressed intracellular antigen. It can be found on the surface of PHA-activated lymphocytes, activated platelets, cytotoxic T cells, NK cells, macrophages, epithelial cells, endothelial cells, and some tumor lines. CD107a is a ligand for E-selectin and galaptin and is reported to be involved in cell adhesion and tumor metastasis.

• NCBI Gene ID:

  3916

• Swiss Prot:

  P11279

• Host:

  Mouse

• Reactivity:

  Human

• Clonality:

  Monoclonal

• Clone:

  H4A3

• Conjugation:

  FITC

• Type:

  Primary Antibodies

• Field of Research:

  Innate Immunity

• Purification:

  The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

• Concentration:

  Batch dependent

• Buffer:

  Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

• Fragment:

  Mouse IgG1, kappa

• Specificity:

  The H4A3 monoclonal antibody specifically reacts with human CD107a, a heavily glycosylated type I membrane glycoprotein.

• Symbol:

  LAMP1

• NCBI Official Name:

  Lysosomal-associated membrane protein 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Chen, J. W., Cha, Y. I. N. G., Yuksel, K. U., Gracy, R. W., August, J. T. (1988) . Isolation and sequencing of a cDNA clone encoding lysosomal membrane glycoprotein mouse LAMP-1. Sequence similarity to proteins bearing onco-differentiation antigens.Journal of Biological Chemistry,263 (18), 8754-8758.

• Background Reference 02:

  Grtzkau, A., Smorodchenko, A., Lippert, U., Kirchhof, L., Artuc, M., Henz, B. M. (2004) . LAMP‐1 and LAMP‐2, but not LAMP‐3, are reliable markers for activation‐induced secretion of human mast cells.Cytometry Part A,61 (1), 62-68.

• Background Reference 03:

  Sarafian, V., Jadot, M., Foidart, J. M., Letesson, J. J., Van den Brule, F., Castronovo, V., ... Coninck, W. D. (1998) . Expression of Lamp‐1 and Lamp‐2 and their interactions with galectin‐3 in human tumor cells.International journal of cancer,75 (1), 105-111.

• Other Product Names:

  LAMPA, CD107a, LGP120, LAMP1

• Tested Applications:

  Flow

• Physical Properties:

  Liquid