CD105 Antibody [SN6] (PE)

• Background:

  The SN6 monoclonal antibody specifically reacts with human CD105 (Endoglin), a 90kDA homodimeric glycoprotein expressed on vascular endothelial cells, activated macrophages, and a subset of bone marrow cells. CD105 is a marker for tumor angiogenesis research by identifying proliferating endothelium. It is also suggested to be involved in embryonic angiogenesis and cellular adhesion.

• NCBI Gene ID:

  2022

• Swiss Prot:

  P17813

• Host:

  Mouse

• Reactivity:

  Human

• Clonality:

  Monoclonal

• Clone:

  SN6

• Conjugation:

  PE

• Type:

  Primary Antibodies

• Field of Research:

  Stem Cell

• Purification:

  The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

• Concentration:

  Batch dependent

• Buffer:

  Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

• Fragment:

  Mouse IgG1

• Specificity:

  The SN6 monoclonal antibody specifically reacts with human CD105 (Endoglin), a 90kDA homodimeric glycoprotein expressed on vascular endothelial cells, activated macrophages, and a subset of bone marrow cells.

• Symbol:

  ENG

• NCBI Official Name:

  Endoglin

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Murayama, T., Yokode, M., Kataoka, H., Imabayashi, T., Yoshida, H., Sano, H., ... Kita, T. (1999) . Intraperitoneal administration of antic-fms monoclonal antibody prevents initial events of atherogenesis but does not reduce the size of advanced lesions in apolipoprotein Edeficient mice.Circulation,99 (13), 1740-1746.

• Background Reference 02:

  Sudo, T., Nishikawa, S., Ogawa, M., Kataoka, H., Ohno, N., Izawa, A., Hayashi, S. (1995) . Functional hierarchy of c-kit and c-fms in intramarrow production of CFU-M.Oncogene,11 (12), 2469-2476.

• Background Reference 03:

  Yoshino, M., Yamazaki, H., Yoshida, H., Niida, S., Nishikawa, S. I., Ryoke, K., ... Hayashi, S. I. (2003) . Reduction of osteoclasts in a critical embryonic period is essential for inhibition of mouse tooth eruption.Journal of Bone and Mineral Research,18 (1), 108-116.

• Other Product Names:

  END, HHT1, ORW1, ENG

• Tested Applications:

  Flow

• Physical Properties:

  Liquid