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CD8a Antibody [2.43] (APC)

CAT: 0223-76-658Size: 0.025 mgDry Ice: NoHazardous: No
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CAT#:0223-76-658Size:0.025 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The 2.43 monoclonal antibody specifically reacts with mouse CD8 antigen. CD8a (the alpha chains) form heterodimers with CD8b (the beta chains) or homodimers (alpha-alpha), which occur as receptors on the surface of the majority of thymocytes. A subpopulation of mature T lymphocytes expresses the CD8 alpha beta (alpha beta TCR T cells), and a subpopulation of intestinal intraepithelial lymphocytes and dendritic cells express CD8a without CD8b. CD8 interacts with the mouse major histocompatibility complex class I (MHC class I) molecules on antigen-presenting cells or epithelial cells.
NCBI Gene ID
12525
Swiss Prot
P01731
Host
Rat
Reactivity
Mouse
Clonality
Monoclonal
Clone
2.43
Conjugation
APC
Type
Primary Antibodies
Field of Research
Immunology
Purification
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.
Fragment
Rat IgG2b
Specificity
The 2.43 monoclonal antibody specifically reacts with mouse CD8 antigen.
Symbol
Cd8a
NCBI Official Name
CD8 antigen, alpha chain
NCBI Organism
Mus musculus
Background Reference 01
Sayos, J., Wu, C., Morra, M., Wang, N., Zhang, X., Allen, D., ... Terhorst, C. (1998) . The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM.Nature,395 (6701), 462-469.
Background Reference 02
Thomas, Y., Sosman, J., Irigoyen, O., Friedman, S. M., Kung, P. C., Goldstein, G., Chess, L. (1980) . Functional analysis of human T cell subsets defined by monoclonal antibodies. I. Collaborative TT interactions in the immunoregulation of B cell differentiation.The Journal of Immunology,125 (6), 2402-2408.
Background Reference 03
Campanelli, R., Palermo, B., Garbelli, S., Mantovani, S., Lucchi, P., Necker, A., ... Giachino, C. (2002) . Human CD8 coreceptor is strictly involved in MHCpeptide tetramerTCR binding and T cell activation.International immunology,14 (1), 39-44.
Other Product Names
Ly-2, Ly-B, Ly-35, Lyt-2, BB154331, Cd8a
Tested Applications
Flow
Physical Properties
Liquid

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