CD8a Antibody [2.43]

CAT: 0223-76-646Size: 0.1 mgDry Ice: NoHazardous: No
CAT#:0223-76-646Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The 2.43 monoclonal antibody specifically reacts with mouse CD8 antigen. CD8a (the alpha chains) form heterodimers with CD8b (the beta chains) or homodimers (alpha-alpha), which occur as receptors on the surface of the majority of thymocytes. A subpopulation of mature T lymphocytes expresses the CD8 alpha beta (alpha beta TCR T cells), and a subpopulation of intestinal intraepithelial lymphocytes and dendritic cells express CD8a without CD8b. CD8 interacts with the mouse major histocompatibility complex class I (MHC class I) molecules on antigen-presenting cells or epithelial cells.
NCBI Gene ID
12525
Swiss Prot
P01731
Host
Rat
Reactivity
Mouse
Clonality
Monoclonal
Clone
2.43
Conjugation
Unconjugated
Type
Primary Antibodies, Functional Antibodies
Field of Research
Immunology
Purification
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.
Fragment
Rat IgG2b
Specificity
The 2.43 monoclonal antibody specifically reacts with mouse CD8 antigen.
Symbol
Cd8a
NCBI Official Name
CD8 antigen, alpha chain
NCBI Organism
Mus musculus
Background Reference 01
Salem, M. L., Hossain, M. S. (2000) . In vivo acute depletion of CD8+ T cells before murine cytomegalovirus infection upregulated innate antiviral activity of natural killer cells. International journal of immunopharmacology,22 (9), 707-718.
Background Reference 02
Kruisbeek, A. M. (1991) . In Vivo Depletion of CD4 and CD8 Specific T Cells.Current protocols in immunology, 4-1.
Background Reference 03
Davies, A., Kalb, S., Liang, B., Aldrich, C. J., Lemonnier, F. A., Jiang, H., ... Soloski, M. J. (2003) . A peptide from heat shock protein 60 is the dominant peptide bound to Qa-1 in the absence of the MHC class Ia leader sequence peptide Qdm.The Journal of Immunology,170 (10), 5027-5033.
Other Product Names
Ly-2, Ly-B, Ly-35, Lyt-2, BB154331, Cd8a
Tested Applications
Flow, Functional Assays, IHC
Physical Properties
Liquid

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