CD95 Antibody [EOS9.1]

• Background:

  The EOS9.1 monoclonal antibody specifically reacts with human CD95, a 45 kDA type I membrane molecule. CD95 is a member of the tumor necrosis factor receptor (TNF-R) family and is involved in the mechanisms that lead to cellular apoptosis. It is expressed on fibroblasts, monocytes, lymphocytes, and neutrophils. CD95 induces apoptosis after binding with CD178 or Fas ligand and the EOS9.1 antibody is reported to be used for inducing apoptosis in Fas-positive cells.

• NCBI Gene ID:

  355

• Swiss Prot:

  P25445

• Host:

  Mouse

• Reactivity:

  Human

• Clonality:

  Monoclonal

• Clone:

  EOS9.1

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies, Functional Antibodies

• Field of Research:

  Other

• Purification:

  The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

• Concentration:

  Batch dependent

• Buffer:

  Phosphate-buffered aqueous solution, ph7.2.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  The product should be stored undiluted at 4˚ C . Do not freeze.

• Fragment:

  Mouse IgM, kappa

• Specificity:

  The EOS9.1 monoclonal antibody specifically reacts with human CD95, a 45 kDA type I membrane molecule. CD95 is a member of the tumor necrosis factor receptor (TNF-R) family and is involved in the mechanisms that lead to cellular apoptosis.

• Symbol:

  FAS

• NCBI Official Name:

  Fas cell surface death receptor

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Deaglio, S., Zubiaur, M., Gregorini, A., Bottarel, F., Ausiello, C. M., Dianzani, U., ... Malavasi, F. (2002) . Human CD38 and CD16 are functionally dependent and physically associated in natural killer cells.Blood,99 (7), 2490-2498.

• Background Reference 02:

  Peruzzi, G., Femnou, L., Gil-Krzewska, A., Borrego, F., Weck, J., Krzewski, K., Coligan, J. E. (2013) . Membrane-type 6 matrix metalloproteinase regulates the activation-induced downmodulation of CD16 in human primary NK cells.The Journal of Immunology,191 (4), 1883-1894.

• Background Reference 03:

  Wirthmueller, U., Kurosaki, T., Murakami, M. S., Ravetch, J. V. (1992) . Signal transduction by Fc gamma RIII (CD16) is mediated through the gamma chain.The Journal of experimental medicine,175 (5), 1381-1390.

• Other Product Names:

  APT1, CD95, FAS1, APO-1, FASTM, ALPS1A, TNFRSF6, FAS

• Tested Applications:

  Flow, Functional Assays

• Physical Properties:

  Liquid