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CD4 Antibody [OKT4]

CAT: 0223-76-319Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-76-319Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The OKT4 monoclonal antibody specifically binds to the CD4 receptor for the human immunodeficiency virus (HIV) . CD4 is a 59 kDa single-chain transmembrane glycoprotein that expressed on the surface of most of the thymocytes, T-helper cells, and in low levels on monocytes and macrophages. CD4 is a co-receptor in the antigen-induced T cell activation (together with the MHC class II) . The OKT4 and the RPA-T4 monoclonal antibodies recognize different epitopes of CD4 and they do not exhibit cross-block binding.
NCBI Gene ID
920
Swiss Prot
P01730
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Clone
OKT4
Conjugation
Unconjugated
Type
Primary Antibodies, Functional Antibodies
Field of Research
Immunology
Purification
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.
Fragment
Mouse IgG2b, kappa
Specificity
The OKT4 monoclonal antibody specifically binds to the CD4 receptor for the human immunodeficiency virus (HIV) .
Symbol
CD4
NCBI Official Name
CD4 molecule
NCBI Organism
Homo sapiens
Background Reference 01
Reinherz, E. L., Kung, P. C., Goldstein, G., Schlossman, S. F. (1979) . Separation of functional subsets of human T cells by a monoclonal antibody.Proceedings of the National Academy of Sciences,76 (8), 4061-4065.
Background Reference 02
Knapp W (1989) Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989.
Background Reference 03
Bour, S. T. E. P. H. A. N. E., Boulerice, F. R. A. N. C. O. I. S., Wainberg, M. A. (1991) . Inhibition of gp160 and CD4 maturation in U937 cells after both defective and productive infections by human immunodeficiency virus type 1.Journal of virology,65 (12), 6387-6396.
Other Product Names
CD4mut, CD4
Tested Applications
Flow, Functional Assays, IF, ICC, IP, WB
Physical Properties
Liquid

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