Products for Research Use Only

CD32 Antibody [6C4] (APC)

CAT: 0223-76-195Size: 100 TestsDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-76-195Size:100 Tests
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
The 6C4 monoclonal antibody specifically recognizes two isoforms of human CD32, Fc gamma RIIA and Fc gamma RIIB. From alternative mRNA splicing, 6 isoforms of CD32 have been reported. CD32 is a 40 kDA polymorphic transmembrane glycoprotein expressed on monocytes, macrophages, graulocytes, B cells, and platelets. The receptor has low affinity toward IgG and is involved in immunomodulation, phagocytosis, and the inflammation response. The 6C4 antibody in a rosette blocking assay is reported to inhibit Ig binding
NCBI Gene ID
2212
Swiss Prot
P12318
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Clone
6C4
Conjugation
APC
Type
Primary Antibodies
Field of Research
Innate Immunity
Purification
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.
Fragment
Mouse IgG1, kappa
Specificity
The 6C4 monoclonal antibody specifically recognizes two isoforms of human CD32, Fc gamma RIIA and Fc gamma RIIB.
Symbol
FCGR2A
NCBI Official Name
Fc fragment of IgG, low affinity IIa, receptor (CD32)
NCBI Organism
Homo sapiens
Background Reference 01
VELY, F., GRUEL, N., MONCUIT, J., COCHET, O., ROUARD, H., DARE, S., ... TEILLAUD, J. L. (1997) . A new set of monoclonal antibodies against human Fc-gamma RII (CD32) and Fc-gamma RIII (CD16) : characterization and use in various assays.Hybridoma,16 (6), 519-528.
Background Reference 02
Liebert, M. A. (1997) . 6C4, 2B2, 3D3.Hybridoma,16 (6) .
Background Reference 03
Bouhlal, H., Martinvalet, D., Teillaud, J. L., Fridman, C., Kazatchkine, M. D., Bayry, J., ... Kaveri, S. V. (2014) . Natural Autoantibodies to Fc-gamma Receptors in Intravenous Immunoglobulins.Journal of clinical immunology, 1-8.
Other Product Names
CD32, FCG2, FcGR, CD32A, CDw32, FCGR2, IGFR2, FCGR2A1, FCGR2A
Tested Applications
Flow
Physical Properties
Liquid