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CD32 Antibody [7.3]

CAT: 0223-33-354Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0223-33-354Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This mAb reacts with a CD32 (FcgRII) epitope (cluster-4) . It displays a stronger reaction with Daudi than with U937 cells. The epitope is located in domain 2 of FcgRIIa. Its Fab'2 fragments block immune complex binding. CD32 (FcgRII) is a type 1 transmembrane glycoprotein that mediates several functions including phagocytosis, cytotoxicity, and immunomodulation as well as platelet aggregation. Three genes (A, B, and C) encode CD32 and at least 6 isoforms are generated via alternative mRNA splicing, i.e., IIa1, IIa2, IIb1, IIb2, IIb3 and IIc. Monocytes/macrophages, placental trophoblasts and endothelial cells express all isoforms. In addition, the IIb isoform is expressed by B cells, and the IIa isoform by platelets, granulocytes and, weakly, by B cells. NK cells and neutrophils express Isoform IIc. CD32 binds weakly to the Fc region of monomeric IgG but more strongly to IgG aggregates and immune complexes.
NCBI Gene ID
2212
Swiss Prot
P12318
Host
Mouse
Reactivity
Human
Immunogen
K562 and FcgRII+L cells were used as the immunogen for the CD32 antibody.
Clonality
Monoclonal
Clone
7.3
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Signal Transduction
Purification
Protein G affinity chromatography
Concentration
0.2 mg/mL
Buffer
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.
Fragment
IgG1, kappa
Symbol
FCGR2A
NCBI Official Name
Fc fragment of IgG, low affinity IIa, receptor (CD32)
NCBI Organism
Homo sapiens
Other Product Names
Low affinity immunoglobulin gamma Fc region receptor II-a, IgG Fc receptor II-a, CDw32, Fc-gamma RII-a, Fc-gamma-RIIa, FcRII-a, CD32, FCGR2A, CD32, FCG2, FCGR2A1, IGFR2
Tested Applications
WB, Functional Assays, Flow, IF
Physical Properties
Liquid

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