CD70 Antibody [FR70]

• Background:

  The FR70 monoclonal antibody specifically binds to mouse CD70, a 30-33 kDA type II transmembrane protein and member of the TNF superfamily. CD70 is the ligand for CD27 and is expressed on dendritic cells, activated B cell, and a subset of activated T cells at lower levels. Its main role is in regulating B cell activation and immunoglobulin synthesis. CD70 expressing cells are able to co-stimulate T cell proliferation and upregulate cytokine production. The FR70 antibody is reported to block the binding of CD70 to CD27.

• NCBI Gene ID:

  21948

• Swiss Prot:

  O55237

• Host:

  Rat

• Reactivity:

  Mouse

• Clonality:

  Monoclonal

• Clone:

  FR70

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies, Functional Antibodies

• Field of Research:

  Immunology

• Purification:

  The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

• Concentration:

  Batch dependent

• Buffer:

  Phosphate-buffered aqueous solution, ph7.2.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  The product should be stored undiluted at 4˚ C . Do not freeze.

• Fragment:

  Rat IgG2b, kappa

• Specificity:

  The FR70 monoclonal antibody specifically binds to mouse CD70, a 30-33 kDA type II transmembrane protein and member of the TNF superfamily.

• Symbol:

  Cd70

• NCBI Official Name:

  CD70 antigen

• NCBI Organism:

  Mus musculus

• Background Reference 01:

  Tesselaar, K., Gravestein, L. A., Van Schijndel, G. M., Borst, J., Van Lier, R. A. (1997) . Characterization of murine CD70, the ligand of the TNF receptor family member CD27.The Journal of Immunology,159 (10), 4959-4965.

• Background Reference 02:

  Oshima, H., Nakano, H., Nohara, C., Kobata, T., Nakajima, A., Jenkins, N. A., ... Okumura, K. (1998) . Characterization of murine CD70 by molecular cloning and mAb.International immunology,10 (4), 517-526.

• Background Reference 03:

  Bullock, T. N., Yagita, H. (2005) . Induction of CD70 on dendritic cells through CD40 or TLR stimulation contributes to the development of CD8+ T cell responses in the absence of CD4+ T cells.The Journal of Immunology,174 (2), 710-717.

• Other Product Names:

  Cd27l, CD27LG, Tnfsf7, Cd70

• Tested Applications:

  Flow, Functional Assays

• Physical Properties:

  Liquid