CD70 Antibody

• Background:

  The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.

• NCBI Gene ID:

  970

• Swiss Prot:

  P32970

• Accession Number:

  P32970

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CD70 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 72-101 amino acids from the Central region of human CD70.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Immunology, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  21 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  CD70

• NCBI Official Name:

  CD70 antigen

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Arimoto-Miyamoto, K., et al. Immunology 130 (1) :137-149 (2010)

• Background Reference 02:

  Shaw, J., et al. Blood 115 (15) :3051-3057 (2010)

• Background Reference 03:

  Yu, S.E., et al. Mol. Cells 29 (2) :217-221 (2010)

• Background Reference 04:

  Kozlowska, A., et al. J. Rheumatol. 37 (1) :53-59 (2010)

• Other Product Names:

  CD70 antigen, CD27 ligand, CD27-L, Tumor necrosis factor ligand superfamily member 7, CD70, CD70, CD27L, CD27LG, TNFSF7

• Tested Applications:

  WB, IHC-P

• Protein ID:

  21431837

• Physical Properties:

  Liquid