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PKR (Ab 446) Antibody

CAT: 0223-79-396Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-79-396Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection.
NCBI Gene ID
5610
Swiss Prot
P19525
Accession Number
NP_001129123.1
Host
Rabbit
Reactivity
Human
Immunogen
PKR (Ab-446) antibody was raised against a peptide sequence around aa.444~448 (K-R-T-R-S) derived from Human PKR.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
68 kDa
Specificity
This antibody detects endogenous level of total PKR protein.
Applications Notes
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
Symbol
EIF2AK2
NCBI Official Name
Eukaryotic translation initiation factor 2-alpha kinase 2
NCBI Organism
Homo sapiens
Background Reference 01
Abujiang Pataer, et, al. (2002) Cancer Res ; 62: 2239. K. D. Ryman, et, al. (2005) J. Virol ; 79: 1487 - 1499. Susana Guerra, et, al. (2006) J. Biol. Chem ; 281: 18734 - 18745.
Other Product Names
PKR, PRKR, EIF2AK1, APT1, FAS1, TNFRSF6, ADRB2, E2AK2, EIF2AK2, EIF2aK
Tested Applications
WB, IHC, IF
Protein ID
208431827
Physical Properties
Liquid

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