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Cortactin (Ab 421) Antibody

CAT: 0223-79-389Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-79-389Size:0.1 mg
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Background
Cortactin is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Two splice variants that encode different isoforms have been identified for this gene.
NCBI Gene ID
2017
Swiss Prot
Q14247
Accession Number
NP_005222.2
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Cortactin (Ab-421) antibody was raised against a peptide sequence around aa.419~423 (P-I-Y-E-D) derived from Human CORTACTIN.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
85 kDa
Specificity
This antibody detects endogenous level of total Cortactin protein.
Applications Notes
Immunohistochemistry: 1:50~1:100
Symbol
CTTN
NCBI Official Name
Cortactin
NCBI Organism
Homo sapiens
Background Reference 01
Luo C, et al. (2006) J Biol Chem ; 281 (40) : 30081-30093Head JA, et al. (2003) Mol Biol Cell ;14 (8) : 3216-3229Salomon AR, et al. (2003) PNAS ; 100 (2) : 443-448 Huang C, et al. (1998) J Biol Chem ; 273 (40) : 25770-25776.
Other Product Names
EMS1, IKBA, MAD3, NFKBI, Amplaxin, CTTN, EMS1, SRC8
Tested Applications
IHC
Protein ID
20357552
Physical Properties
Liquid

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