P70 S6 Kinase (Ab 411) Antibody

• Background:

  Phosphorylates specifically ribosomal protein S6 in response to insulin or several classes of mitogens. Promotes protein synthesis by phosphorylating PDCD4 at 'Ser-67' and targeting it for degradation.

• NCBI Gene ID:

  6198

• Swiss Prot:

  P23443

• Accession Number:

  NP_003152.1

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  P70 S6 Kinase (Ab-411) antibody was raised against a peptide sequence around aa. 409~413 (I-R-S-P-R) derived from Human p70 S6 Kinase.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Apoptosis, Cancer

• Purification:

  Antibodies were purified by affinity-chromatography using epitope-specific peptide.

• Concentration:

  1 mg/mL

• Buffer:

  Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store antibody at -20˚ C for up to one year.

• Calculated Molecular Weight:

  70 85 kDa

• Specificity:

  This antibody detects endogenous level of total p70 S6 Kinase protein.

• Applications Notes:

  Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200

• Symbol:

  RPS6KB1

• NCBI Official Name:

  Ribosomal protein S6 kinase, 70kDa, polypeptide 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Satoru Eguchi et al. (1999) J Biol Chem, Vol. 274: 36843-36851Papst PJ, et al. (1998) J Biol Chem. 273 (24) : 15077-84. Ulrike Krause et al. (2002) Eur. J. Biochem. 269: 3751-3759 cLe, X. F, et al. (2003) Oncogene 22: 484–97

• Other Product Names:

  S6K, PS6K, S6K1, STK14A, p70-S6K, p70S6KA, p70-alpha, S6K-beta-1, p70 (S6K) -alpha, ABCP, BCRP, BCRP1, MXR, KS6B1, P70-S6K, RPS6KB1, S6K

• Tested Applications:

  WB, IHC, IF

• Protein ID:

  4506737

• Physical Properties:

  Liquid