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Pyk2 (Ab 402) Antibody

CAT: 0223-79-362Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-79-362Size:0.1 mg
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Background
Involved in calcium induced regulation of ion channel and activation of the map kinase signaling pathway. May represent an important signaling intermediate between neuropeptide activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. Interacts with the SH2 domain of Grb2. May phosphorylate the voltage-gated potassium channel protein Kv1.2. Its activation is highly correlated with the stimulation of c-Jun N-terminal kinase activity. Involved in osmotic stress-dependent SNCA 'Tyr-125' phosphorylation.
NCBI Gene ID
2185
Swiss Prot
Q14289
Accession Number
NP_004094.3
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Pyk2 (Ab-402) antibody was raised against a peptide sequence around aa.400~404 (D-I-Y-A-E) derived from Human Pyk2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
140 kDa
Specificity
This antibody detects endogenous level of total Pyk2 protein.
Applications Notes
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
Symbol
PTK2B
NCBI Official Name
Protein tyrosine kinase 2 beta
NCBI Organism
Homo sapiens
Background Reference 01
Gluck SL, et al. (2004) J Clin Invest; 114 (12) : 1696-1699Benzing T, et al. (2001) Proc Natl Acad Sci U S A; 98 (17) : 9784-9789Tian D, et al. (2002) Mol Cell Biol; 22 (8) : 2650-2662Lu Z, et al. (2001) Mol Cell Biol; 21 (12) : 4016-4031Krishnan HH, et al. (2006) J Virol; 80 (3) : 1167-1180
Other Product Names
PKB, PTK, CAKB, FAK2, PYK2, CADTK, FADK2, RAFTK, TC25, MIG5, FADK 2, Focal adhesion kinase 2, PTK2B, Proline-rich tyrosine kinase 2 RAFTK
Tested Applications
WB, IHC, IF
Protein ID
27886584
Physical Properties
Liquid

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