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BAD (phospho Ser136) Antibody

CAT: 0223-79-135Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-79-135Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by BAD gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform.
NCBI Gene ID
572
Swiss Prot
Q92934
Accession Number
NP_004313.1
Host
Rabbit
Reactivity
Mouse
Immunogen
BAD (Phospho-Ser136) antibody was raised against a peptide sequence around phosphorylation site of serine136 (S-R-S (p) -A-P) derived from Mouse BAD.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Phospho-Specific, Apoptosis, Cancer
Purification
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
Phospho-Specific
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
23 kDa
Specificity
This antibody detects endogenous level of BAD only when phosphorylated at serine136.
Applications Notes
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Symbol
BAD
NCBI Official Name
BCL2-associated agonist of cell death
NCBI Organism
Murine
Background Reference 01
Wang XQ, et al. (2001) . J Biol Chem. 276 (48) : 44504-44511. Lee YI, et al. (2001) . J Biol Chem. 276 (20) : 16969-16977. Maiti D, et al. (2001) . J Biol Chem. 276 (1) : 329-333.
Other Product Names
BBC2, BCL2L8, BBC6
Tested Applications
WB, IHC
Protein ID
10835069
Physical Properties
Liquid

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