CD31 Antibody [2F7B2]

• Background:

  CD31, also known as platelet endothelial cell adhesion molecule 1 (PECAM1), is a type I integral membrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors.It is constitutively expressed on the surface of endothelial cells, and concentrated at the junction between them. The antibody reacts with the murine form of the Platelet-Endothelial Cell Adhesion Molecule. The reactivity of the antibody is restricted to the isoform of the molecule that is selectively expressed by endothelial cells.The antigen is predominantly present at the lateral borders of endothelial cells as described for human PECAM-1.It is also weakly expressed on many peripheral lymphoid cells and platelets.CD31 has been used to measure angiogenesis in association with tumor recurrence. Other studies have also indicated that CD31 and CD34 can be used as markers for myeloid progenitor cells and recognize different subsets of myeloid leukemia infiltrates (granular sarcomas) .

• NCBI Gene ID:

  5175

• Swiss Prot:

  P16284

• Accession Number:

  P16284

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Ni-NTA purified recombinant CD31 expressed in E. Coli strain BL21 (DE3) .

• Clonality:

  Monoclonal

• Clone:

  2F7B2

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Innate Immunity

• Concentration:

  Batch dependent

• Buffer:

  Ascitic fluid containing 0.03% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  CD31 monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG1

• Symbol:

  PECAM1

• NCBI Official Name:

  Platelet/endothelial cell adhesion molecule 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Mayr U et al. Circ Res 98:412-20 (2006) .

• Background Reference 02:

  Bingle L et al. Br J Cancer 94:101-7 (2006) .

• Background Reference 03:

  Wynne F et al. Reproduction 131:721-32 (2006) .

• Other Product Names:

  EndoCAM, PECAM-1, CD31, PECA1, GPIIA', endoCAM, CD31/EndoCAM

• Tested Applications:

  ELISA, WB, IHC

• Protein ID:

  129747