DNAJC2 Antibody

• Background:

  This gene is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors. This gene has a pseudogene on chromosome 6.

• NCBI Gene ID:

  27000

• Swiss Prot:

  Q99543

• Accession Number:

  Q99543

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This DNAJC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 226-255 amino acids from the Central region of human DNAJC2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Monkey

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  72 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  DNAJC2

• NCBI Official Name:

  DnaJ homolog subfamily C member 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Hatzold, J., et al. PLoS Biol. (4), E84 (2008) :

• Background Reference 02:

  Olsen, J.V., et al. Cell 127 (3) :635-648 (2006)

• Background Reference 03:

  Otto, H., et al. Proc. Natl. Acad. Sci. U.S.A. 102 (29) :10064-10069 (2005)

• Other Product Names:

  DnaJ homolog subfamily C member 2, M-phase phosphoprotein 11, Zuotin-related factor 1, DnaJ homolog subfamily C member 2, N-terminally processed, DNAJC2, MPHOSPH11, MPP11, ZRF1

• Tested Applications:

  WB

• Protein ID:

  296439472

• Physical Properties:

  Liquid