CDC45L Antibody

CAT: 0223-64-163Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-64-163Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Multiple polyadenlyation sites of this gene are reported.
NCBI Gene ID
8318
Swiss Prot
O75419
Accession Number
O75419
Host
Rabbit
Reactivity
Human
Immunogen
This CDC45L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 236-263 amino acids from the Central region of human CDC45L.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
66 kDa
Fragment
Rabbit Ig
Symbol
CDC45
NCBI Official Name
Cell division control protein 45 homolog
NCBI Organism
Homo sapiens
Background Reference 01
Chowdhury, A., et al. Mol. Cell. Biol. 30 (6) :1495-1507 (2010)
Background Reference 02
Im, J.S., et al. Proc. Natl. Acad. Sci. U.S.A. 106 (37) :15628-15632 (2009)
Background Reference 03
Ballabeni, A., et al. J. Biol. Chem. 284 (5) :3028-3036 (2009)
Background Reference 04
Enjuanes, A., et al. Cancer Res. 68 (24) :10178-10186 (2008)
Other Product Names
Cell division control protein 45 homolog, PORC-PI-1, CDC45, CDC45L, CDC45L2
Tested Applications
WB, IHC-P, Flow
Physical Properties
Liquid

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