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STX1A Antibody

CAT: 0223-64-127Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-64-127Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein) -Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc) . Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis.
NCBI Gene ID
6804
Swiss Prot
Q16623
Accession Number
Q16623
Host
Rabbit
Reactivity
Human
Immunogen
This STX1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 29-57 amino acids from the N-terminal region of human STX1A.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
33 kDa
Fragment
Rabbit Ig
Symbol
STX1A
NCBI Official Name
Syntaxin-1A
NCBI Organism
Homo sapiens
Background Reference 01
Yoshida, T., et al. Int. J. Mol. Med. 24 (2) :233-246 (2009)
Background Reference 02
Hamdan, F.F., et al. Ann. Neurol. 65 (6) :748-753 (2009)
Background Reference 03
Corominas, R., et al. Neurosci. Lett. 455 (2) :105-109 (2009)
Background Reference 04
Chen, C.S., et al. J. Biol. Chem. 284 (11) :6877-6884 (2009)
Other Product Names
Syntaxin-1A, Neuron-specific antigen HPC-1, STX1A, STX1
Tested Applications
WB, IHC-P, Flow
Protein ID
2501084
Physical Properties
Liquid

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