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IDH3G Antibody

CAT: 0223-64-122Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-64-122Size:400 µL
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Background
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD (+) as the electron acceptor and the other NADP (+) . Five isocitrate dehydrogenases have been reported: three NAD (+) -dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP (+) -dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD (+) -dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the gamma subunit of one isozyme of NAD (+) -dependent isocitrate dehydrogenase. This gene is a candidate gene for periventricular heterotopia.
NCBI Gene ID
3421
Swiss Prot
P51553
Accession Number
P51553
Host
Rabbit
Reactivity
Human
Immunogen
This IDH3G antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 366-393 amino acids from the C-terminal region of human IDH3G.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Monkey
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
43 kDa
Fragment
Rabbit Ig
Symbol
IDH3G
NCBI Official Name
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
NCBI Organism
Homo sapiens
Background Reference 01
Bzymek, K.P., et al. Biochemistry 46 (18) :5391-5397 (2007)
Background Reference 02
Soundar, S., et al. J. Biol. Chem. 281 (30) :21073-21081 (2006)
Background Reference 03
Simpson, J.C., et al. EMBO Rep. 1 (3) :287-292 (2000)
Background Reference 04
Weiss, C., et al. Biochemistry 39 (7) :1807-1816 (2000)
Other Product Names
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial, Isocitric dehydrogenase subunit gamma, NAD (+) -specific ICDH subunit gamma, IDH3G
Tested Applications
WB, Flow
Protein ID
1708404
Physical Properties
Liquid

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