PEX12 Antibody

• Background:

  Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle.

• NCBI Gene ID:

  5193

• Swiss Prot:

  O00623

• Accession Number:

  O00623

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PEX12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 131-158 amino acids from the Central region of human PEX12.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  41 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  PEX12

• NCBI Official Name:

  Peroxisome assembly protein 12

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Zeharia, A., et al. J. Hum. Genet. 52 (7) :599-606 (2007)

• Background Reference 02:

  Mano, S., et al. Plant J. 47 (4) :604-618 (2006)

• Background Reference 03:

  Gootjes, J., et al. Hum. Mutat. 24 (2) :130-139 (2004)

• Other Product Names:

  Peroxisome assembly protein 12, Peroxin-12, Peroxisome assembly factor 3, PAF-3, PEX12, PAF3

• Tested Applications:

  WB

• Physical Properties:

  Liquid