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CHMP4B Antibody

CAT: 0223-63-990Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-63-990Size:400 µL
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Background
CHMP4B is a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies.
NCBI Gene ID
128866
Swiss Prot
Q9H444
Accession Number
Q9H444
Host
Rabbit
Reactivity
Human
Immunogen
This CHMP4B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 51-79 amino acids from the N-terminal region of human CHMP4B.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Chicken, Zebrafish, Mouse, Xenopus
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
25 kDa
Fragment
Rabbit Ig
Symbol
CHMP4B
NCBI Official Name
Charged multivesicular body protein 4b
NCBI Organism
Homo sapiens
Background Reference 01
Zhou, X., et al. Biochem. J. 418 (2) :277-284 (2009)
Background Reference 02
McCullough, J., et al. Proc. Natl. Acad. Sci. U.S.A. 105 (22) :7687-7691 (2008)
Background Reference 03
Ichioka, F., et al. FEBS J. 275 (4) :682-692 (2008)
Background Reference 04
Hanson, P.I., et al. J. Cell Biol. 180 (2) :389-402 (2008)
Other Product Names
Charged multivesicular body protein 4b, Chromatin-modifying protein 4b, CHMP4b, SNF7 homolog associated with Alix 1, SNF7-2, hSnf7-2, Vacuolar protein sorting-associated protein 32-2, Vps32-2, hVps32-2, CHMP4B, C20orf178, SHAX1
Tested Applications
WB, IHC-P, Flow
Protein ID
24636296
Physical Properties
Liquid

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GWB-MT029BCHMP4B Antibody

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