ADRA1B Antibody

• Background:

  Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This protein encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This protein comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region.

• NCBI Gene ID:

  147

• Swiss Prot:

  P35368

• Accession Number:

  P35368

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This ADRA1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 270-297 amino acids from the Central region of human ADRA1B.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience, Signal Transduction, Growth Factors

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rabbit, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  57 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  ADRA1B

• NCBI Official Name:

  Alpha-1B adrenergic receptor

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Mathias, R.A., J. Allergy Clin. Immunol. 125 (2), 336-346 (2010)

• Background Reference 02:

  Jensen, B.C., Circ Heart Fail (6), 654-663 (2009)

• Background Reference 03:

  Gratacos, M., Am. J. Med. Genet.Neuropsychiatr. Genet. 150B (6), 808-816 (2009)

• Other Product Names:

  Alpha-1B adrenergic receptor, Alpha-1B adrenoreceptor, Alpha-1B adrenoceptor, ADRA1B

• Tested Applications:

  WB, IHC-P

• Protein ID:

  116241241

• Physical Properties:

  Liquid