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ADRA2C Antibody

CAT: 0223-57-834Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-834Size:400 µL
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Background
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences.
NCBI Gene ID
152
Swiss Prot
P18825
Accession Number
P18825
Host
Rabbit
Reactivity
Human
Immunogen
This ADRA2C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 354-382 amino acids from the C-terminal region of human ADRA2C.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Signal Transduction, Growth Factors
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
50 kDa
Fragment
Rabbit Ig
Symbol
ADRA2C
NCBI Official Name
Alpha-2C adrenergic receptor
NCBI Organism
Homo sapiens
Background Reference 01
Chen, Q.J., et al. Clin. Biochem. 43 (15) :1201-1204 (2010)
Background Reference 02
Maqbool, A., et al. J. Hypertens. 28 (10) :2084-2093 (2010)
Background Reference 03
Saus, E., et al.Psychiatr Res 44 (14) :971-978 (2010)
Background Reference 04
Gao, Y., et al. Ophthalmology (2010) In press :
Other Product Names
Alpha-2C adrenergic receptor, Alpha-2 adrenergic receptor subtype C4, Alpha-2C adrenoreceptor, Alpha-2C adrenoceptor, Alpha-2CAR, ADRA2C, ADRA2L2, ADRA2RL2
Tested Applications
WB, IHC-P
Protein ID
20141211
Physical Properties
Liquid

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