ADRA2C Antibody

• Background:

  Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences.

• NCBI Gene ID:

  152

• Swiss Prot:

  P18825

• Accession Number:

  P18825

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This ADRA2C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 354-382 amino acids from the C-terminal region of human ADRA2C.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience, Signal Transduction, Growth Factors

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  50 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  ADRA2C

• NCBI Official Name:

  Alpha-2C adrenergic receptor

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Chen, Q.J., et al. Clin. Biochem. 43 (15) :1201-1204 (2010)

• Background Reference 02:

  Maqbool, A., et al. J. Hypertens. 28 (10) :2084-2093 (2010)

• Background Reference 03:

  Saus, E., et al.Psychiatr Res 44 (14) :971-978 (2010)

• Background Reference 04:

  Gao, Y., et al. Ophthalmology (2010) In press :

• Other Product Names:

  Alpha-2C adrenergic receptor, Alpha-2 adrenergic receptor subtype C4, Alpha-2C adrenoreceptor, Alpha-2C adrenoceptor, Alpha-2CAR, ADRA2C, ADRA2L2, ADRA2RL2

• Tested Applications:

  WB, IHC-P

• Protein ID:

  20141211

• Physical Properties:

  Liquid