RAB8A Antibody

• Background:

  The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. Anessential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. RAB8A is a member of the peptidase T1A family, that is a 20S core alpha subunit. A pseudogene has been identified on the Y chromosome.

• NCBI Gene ID:

  4218

• Swiss Prot:

  P61006

• Accession Number:

  P61006

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This RAB8A antibody is generated from rabbits immunized with human RAB8A recombinant protein.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  24 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  RAB8A

• NCBI Official Name:

  Ras-related protein Rab-8A

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kato, S., et.al., Gene 150 (2), 243-250 (1994)

• Background Reference 02:

  Bey, F., et.al., Mol. Gen. Genet. 237 (1-2), 193-205 (1993)

• Other Product Names:

  Ras-related protein Rab-8A, Oncogene c-mel, RAB8A, MEL, RAB8

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  46810392

• Physical Properties:

  Liquid