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CYP7A1 Antibody

CAT: 0223-63-325Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-63-325Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CYP7A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the primary mechanism for the removal of cholesterol from the body.
NCBI Gene ID
1581
Swiss Prot
P22680
Accession Number
P22680
Host
Rabbit
Reactivity
Human
Immunogen
This CYP7A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 476-504 amino acids from the C-terminal region of human CYP7A1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Rb
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
58 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
CYP7A1
NCBI Official Name
Cholesterol 7-alpha-monooxygenase
NCBI Organism
Homo sapiens
Background Reference 01
Lenicek, M., J. Lipid Res. 49 (12), 2664-2667 (2008)
Background Reference 02
Nelson, D.R., Pharmacogenetics 14 (1), 1-18 (2004)
Other Product Names
Cholesterol 7-alpha-monooxygenase, CYPVII, Cholesterol 7-alpha-hydroxylase, Cytochrome P450 7A1, CYP7A1, CYP7
Tested Applications
WB
Protein ID
544084
Physical Properties
Liquid

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