ROR2 Antibody

• Background:

  ROR2 is a tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development. This Type I membrane protein is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Defects in ROR2 are a cause of brachydactyly type B1 (BDB1) . BDB1 is an autosomal dominant skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In BDB1 the middle phalanges are short but in addition the terminal phalanges are rudimentary or absent. Both fingers and toes are affected. The thumbs and big toes are usually deformed. Defects in ROR2 are a cause of recessive Robinow syndrome (RRS) . RRS is an autosomal disorder characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly and a dysmorphic facial appearance. The protein contains 1 frizzled (FZ) domain, 1 immunoglobulin-like C2-type domain, and 1 kringle domain.

• NCBI Gene ID:

  4920

• Swiss Prot:

  Q01974

• Accession Number:

  Q01974

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This ROR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-50 amino acids from the N-terminal region of human ROR2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  105 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  ROR2

• NCBI Official Name:

  Tyrosine-protein kinase transmembrane receptor ROR2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Afzal, A.R., et al., Nat. Genet. 25 (4) :419-422 (2000) .

• Background Reference 02:

  Oldridge, M., et al., Nat. Genet. 24 (3) :275-278 (2000) .

• Background Reference 03:

  Van Bokhoven, H., et al., Nat. Genet. 25 (4) :423-426 (2000) .

• Background Reference 04:

  Schwabe, G.C., et al., Am. J. Hum. Genet. 67 (4) :822-831 (2000) .

• Other Product Names:

  Tyrosine-protein kinase transmembrane receptor ROR2, Neurotrophic tyrosine kinase, receptor-related 2, ROR2, NTRKR2

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  90110767

• Physical Properties:

  Liquid