IGF1 Receptor Antibody

• Background:

  The IGF1R receptor binds insulin-like growth factor with a high affinity and plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. The protein possess tyrosine kinase activity.

• NCBI Gene ID:

  3480

• Swiss Prot:

  P08069

• Accession Number:

  P08069

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This IGF1 Receptor (IGF1R) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-51 amino acids from the N-terminal region of human IGF1 Receptor (IGF1R) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Neuroscience, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  155 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  IGF1R

• NCBI Official Name:

  Insulin-like growth factor 1 receptor

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Song, R.X., et al., Proc. Natl. Acad. Sci. U.S.A. 101 (7) :2076-2081 (2004) .

• Background Reference 02:

  Zhao, H., et al., Oncogene 23 (3) :786-794 (2004) .

• Background Reference 03:

  Lu, Y., et al., Biochem. Biophys. Res. Commun. 313 (3) :709-715 (2004) .

• Background Reference 04:

  Hakam, A., et al., Dig. Dis. Sci. 48 (10) :1972-1978 (2003) .

• Other Product Names:

  Insulin-like growth factor 1 receptor, Insulin-like growth factor I receptor, IGF-I receptor, CD221, Insulin-like growth factor 1 receptor alpha chain, Insulin-like growth factor 1 receptor beta chain, IGF1R

• Tested Applications:

  WB, IHC-P

• Protein ID:

  124240

• Physical Properties:

  Liquid