IGFBP3 Antibody

• Background:

  IGFBP3 is a member of the insulin-like growth factor binding protein (IGFBP) family with an IGFBP domain and a thyroglobulin type-I domain. This protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors.

• NCBI Gene ID:

  3486

• Swiss Prot:

  P17936

• Accession Number:

  P17936

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Hamster

• Immunogen:

  This IGFBP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 162-189 amino acids from human IGFBP3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Pig, Bovine

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  32 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  IGFBP3

• NCBI Official Name:

  Insulin-like growth factor-binding protein 3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Muzumdar, R.H., Diabetes 55 (10), 2788-2796 (2006) Novosyadlyy, R., Growth Horm. IGF Res. 15 (5), 313-323 (2005)

• Other Product Names:

  Insulin-like growth factor-binding protein 3, IBP-3, IGF-binding protein 3, IGFBP-3, IGFBP3, IBP3

• Tested Applications:

  WB

• Protein ID:

  146327827

• Physical Properties:

  Liquid