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EGFR Antibody

CAT: 0223-63-070Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-63-070Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
EGFR is a transmembrane glycoprotein that is a member of a family of protein tyrosine kinases crucial in maintaining a normal balance in cell growth and development. A prototype member of the type 1 receptor tyrosine kinases, EGFR is encoded by the cellular oncogene cerbB1. EGFR has an extracellular ligand binding domain, a single transmembrane region, and cytoplasmic domain which is composed of a tyrosine kinase domain and a carboxy terminal domain. The carboxy terminal domain contains at least four tyrosine autophosphorylation sites. Increased production or activation of EGFR has been associated with poor prognosis in a variety of tumors. EGFR overexpression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma.
NCBI Gene ID
1956
Swiss Prot
P00533
Accession Number
P00533
Host
Rabbit
Reactivity
Human
Immunogen
This EGFR antibody is generated from rabbits immunized with EGFR his fusion protein.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
134 kDa
Fragment
Rabbit Ig
Symbol
EGFR
NCBI Official Name
Epidermal growth factor receptor
NCBI Organism
Homo sapiens
Background Reference 01
Aifa, S., et al., Exp. Cell Res. 302 (1) :108-114 (2005) .
Background Reference 02
Adams, T.E., et al., Growth Factors 22 (2) :89-95 (2004) .
Background Reference 03
Ichinose, J., et al., Biochem. Biophys. Res. Commun. 324 (3) :1143-1149 (2004) .
Background Reference 04
Kuribayashi, A., et al., Endocrinology 145 (11) :4976-4984 (2004) .
Other Product Names
Epidermal growth factor receptor, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, EGFR, ERBB, ERBB1, HER1
Tested Applications
WB, IHC-P
Protein ID
2811086
Physical Properties
Liquid

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