ADAMTS13 Antibody

• Background:

  ADAMTS13 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme is the von Willebrand Factor (vWF) -cleaving protease, which is responsible for cleaving at the site of Tyr842-Met843 of the vWF molecule. A deficiency of this enzyme is associated with thrombotic thrombocytopenic purpura.

• NCBI Gene ID:

  11093

• Swiss Prot:

  Q76LX8

• Accession Number:

  Q76LX8

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This ADAMTS13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 829-858 amino acids from the Central region of human ADAMTS13.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  154 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  ADAMTS13

• NCBI Official Name:

  A disintegrin and metalloproteinase with thrombospondin motifs 13

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Zheng X., Chung D., Takayama T.K.J. Biol. Chem. 276:41059-41063 (2001)

• Background Reference 02:

  Levy G.G., Nichols W.C.Nature 413:488-494 (2001)

• Background Reference 03:

  Cal S., Obaya A.J., Llamazares M., Garabaya C.Gene 283:49-62 (2002)

• Background Reference 04:

  Zheng X., Nishio K., Majerus E.M.J. Biol. Chem. 278:30136-30141 (2003)

• Other Product Names:

  A disintegrin and metalloproteinase with thrombospondin motifs 13, ADAM-TS 13, ADAM-TS13, ADAMTS-13, von Willebrand factor-cleaving protease, vWF-CP, vWF-cleaving protease, ADAMTS13, C9orf8

• Tested Applications:

  WB, IHC-P

• Protein ID:

  74749836

• Physical Properties:

  Liquid