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ADAMTS13 Antibody

CAT: 0223-62-911Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-62-911Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
ADAMTS13 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme is the von Willebrand Factor (vWF) -cleaving protease, which is responsible for cleaving at the site of Tyr842-Met843 of the vWF molecule. A deficiency of this enzyme is associated with thrombotic thrombocytopenic purpura.
NCBI Gene ID
11093
Swiss Prot
Q76LX8
Accession Number
Q76LX8
Host
Rabbit
Reactivity
Human
Immunogen
This ADAMTS13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 829-858 amino acids from the Central region of human ADAMTS13.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
154 kDa
Fragment
Rabbit Ig
Symbol
ADAMTS13
NCBI Official Name
A disintegrin and metalloproteinase with thrombospondin motifs 13
NCBI Organism
Homo sapiens
Background Reference 01
Zheng X., Chung D., Takayama T.K.J. Biol. Chem. 276:41059-41063 (2001)
Background Reference 02
Levy G.G., Nichols W.C.Nature 413:488-494 (2001)
Background Reference 03
Cal S., Obaya A.J., Llamazares M., Garabaya C.Gene 283:49-62 (2002)
Background Reference 04
Zheng X., Nishio K., Majerus E.M.J. Biol. Chem. 278:30136-30141 (2003)
Other Product Names
A disintegrin and metalloproteinase with thrombospondin motifs 13, ADAM-TS 13, ADAM-TS13, ADAMTS-13, von Willebrand factor-cleaving protease, vWF-CP, vWF-cleaving protease, ADAMTS13, C9orf8
Tested Applications
WB, IHC-P
Protein ID
74749836
Physical Properties
Liquid

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