TMPRSS2 Antibody

• Background:

  TMPRSS2 is a protein that belongs to the serine protease family. The protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. Its gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage.

• NCBI Gene ID:

  7113

• Swiss Prot:

  O15393

• Accession Number:

  O15393

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This TMPRSS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 314-343 amino acids from the Central region of human TMPRSS2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Neuroscience

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  54 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  TMPRSS2

• NCBI Official Name:

  Transmembrane protease serine 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Gopalan, A., Cancer Res. 69 (4), 1400-1406 (2009)

• Background Reference 02:

  Hofer, M.D., Cancer Res. 69 (2), 640-646 (2009)

• Other Product Names:

  Transmembrane protease serine 2, 3421-, Serine protease 10, Transmembrane protease serine 2 non-catalytic chain, Transmembrane protease serine 2 catalytic chain, TMPRSS2, PRSS10

• Tested Applications:

  WB, Flow

• Physical Properties:

  Liquid