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TMPRSS2 (CT) Antibody

CAT: 0223-9569-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-9569-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
TMPRSS2 Antibody: TMPRSS2 is a plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells. It facilitates human coronaviruses SARS-CoV and SARS-CoV-2 infections via two independent mechanisms, proteolytic cleavage of ACE2 receptor which promotes viral uptake, and cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry. It proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV) . TMPRSS2 is essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9), and it is involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity.
NCBI Gene ID
7113
Swiss Prot
O15393
Accession Number
O15393
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
9569
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Infectious Disease, COVID-19
Purification
TMPRSS2 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1203 – Human Testis Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Monkey (100%) ; Gorilla (100%) ; Cat (92%) .
Buffer
TMPRSS2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
TMPRSS2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Isoform
Human TMPRSS2 has 2 isoforms, including isoform 1 (492aa, 54kD) and isoform 2 (529aa, 57.7kD) . Mouse TMPRSS2 has 1 isoform (490aa, 54kD) . Rat TMPRSS2 has one isoform (490aa, 53kD) . 9569 can detect TMPRSS2 in human, mouse and rat.
Symbol
TMPRSS2
Positive Control 2
Cat. No. 17-003 – A549 Cell Slide
NCBI Official Name
Transmembrane serine protease 2
NCBI Organism
Homo sapiens
Background Reference 01
Lucas et al. Cancer Discov. 2014; 4 (11) :1310-25.
Background Reference 02
Ko et al. Cancer Res. 2015; 75 (14) :2949-60.
Background Reference 03
Zang et al. Sci. Immunol. 2020; 5 (47) :eabc3582.
Other Product Names
TMPRSS2 Antibody: Transmembrane protease serine 2, Serine protease 10, PRSS10, Transmembrane protease serine 2 non-catalytic chain, Transmembrane protease serine 2 catalytic chain.
Tested Applications
ELISA, IF, WB
Protein ID
115502469
Physical Properties
Liquid

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