LINGO1 Antibody

• Background:

  LINGO1 is a functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. It is also an important negative regulator of oligodentrocyte differentiation and axonal myelination.

• NCBI Gene ID:

  84894

• Swiss Prot:

  Q96FE5

• Accession Number:

  Q96FE5

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This LINGO1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 57-85 amino acids from the N-terminal region of human LINGO1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Neuroscience

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Monkey, Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  70 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  LINGO1

• NCBI Official Name:

  Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Inoue, H., Proc. Natl. Acad. Sci. U.S.A. 104 (36), 14430-14435 (2007)

• Background Reference 02:

  Satoh, J., Neuropathol. Appl. Neurobiol. 33 (1), 99-107 (2007)

• Background Reference 03:

  Mosyak, L., J. Biol. Chem. 281 (47), 36378-36390 (2006)

• Background Reference 04:

  Mi, S., Nat. Neurosci. (3), 221-228 (2004)

• Other Product Names:

  Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1, Leucine-rich repeat and immunoglobulin domain-containing protein 1, Leucine-rich repeat neuronal protein 1, Leucine-rich repeat neuronal protein 6A, LINGO1, LERN1, LRRN6A

• Tested Applications:

  WB

• Protein ID:

  74760819

• Physical Properties:

  Liquid