STK38 Antibody

• Background:

  Stk38, also known as NUCLEAR DBF2-RELATED PROTEIN, contains 1 protein kinase domain that interacts with mob1 and mob2.The homodimeric s100b binds to two molecules of stk38. It is ubiquitously expressed with highest levels observed in peripheral blood leukocytes. Stk38 activated by binding of s100b which releases autoinhibitory n-lobe interactions, enabling atp to bind and the autophosphorylation of ser-281. thr-444 then undergoes calcium- dependent phosphorylation by an upstream kinase. Interactions between phosphorylated thr-444 and the n-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of mob1/mobkl1a and mob2/hcca2 to the n-terminal of stk38.

• NCBI Gene ID:

  11329

• Swiss Prot:

  Q15208

• Accession Number:

  Q15208

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This STK38 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 410-439 amino acids from the C-terminal region of human STK38.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  54 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  STK38

• NCBI Official Name:

  Serine/threonine-protein kinase 38

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Devroe, E., et al., J. Biol. Chem. 279 (23) :24444-24451 (2004) .

• Background Reference 02:

  Tamaskovic, R., et al., J. Biol. Chem. 278 (9) :6710-6718 (2003) .

• Background Reference 03:

  Tripodis, N., et al., Genome Res. 8 (6) :631-643 (1998) .

• Background Reference 04:

  Millward, T., et al., Proc. Natl. Acad. Sci. U.S.A. 92 (11) :5022-5026 (1995) .

• Other Product Names:

  Serine/threonine-protein kinase 38, NDR1 protein kinase, Nuclear Dbf2-related kinase 1, STK38 {ECO:0000312|EMBL:AAH120851}

• Tested Applications:

  WB

• Protein ID:

  56749457

• Physical Properties:

  Liquid