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STK38 Antibody

CAT: 0223-62-638Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-62-638Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Stk38, also known as NUCLEAR DBF2-RELATED PROTEIN, contains 1 protein kinase domain that interacts with mob1 and mob2.The homodimeric s100b binds to two molecules of stk38. It is ubiquitously expressed with highest levels observed in peripheral blood leukocytes. Stk38 activated by binding of s100b which releases autoinhibitory n-lobe interactions, enabling atp to bind and the autophosphorylation of ser-281. thr-444 then undergoes calcium- dependent phosphorylation by an upstream kinase. Interactions between phosphorylated thr-444 and the n-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of mob1/mobkl1a and mob2/hcca2 to the n-terminal of stk38.
NCBI Gene ID
11329
Swiss Prot
Q15208
Accession Number
Q15208
Host
Rabbit
Reactivity
Human
Immunogen
This STK38 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 410-439 amino acids from the C-terminal region of human STK38.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
54 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
STK38
NCBI Official Name
Serine/threonine-protein kinase 38
NCBI Organism
Homo sapiens
Background Reference 01
Devroe, E., et al., J. Biol. Chem. 279 (23) :24444-24451 (2004) .
Background Reference 02
Tamaskovic, R., et al., J. Biol. Chem. 278 (9) :6710-6718 (2003) .
Background Reference 03
Tripodis, N., et al., Genome Res. 8 (6) :631-643 (1998) .
Background Reference 04
Millward, T., et al., Proc. Natl. Acad. Sci. U.S.A. 92 (11) :5022-5026 (1995) .
Other Product Names
Serine/threonine-protein kinase 38, NDR1 protein kinase, Nuclear Dbf2-related kinase 1, STK38 {ECO:0000312|EMBL:AAH120851}
Tested Applications
WB
Protein ID
56749457
Physical Properties
Liquid

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